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CRF within the parvocellular neurons of your hypothalamic paraventricular nucleus is the number 1 secretagogue toward HPA axis in reaction to help you an intimidating stimuli. AVP synergizes that have CRF during the HPA axis activation. Regarding HPA axis, CRF comes out about paraventricular nucleus and you can serves into the receptors on prior pituitary in order to elicit development and you may release of adrenocorticotropic hormonal (ACTH), which is released systemi-cally and you may activates production and you can launch of glucocorticoids on adrenal cortex. From inside the individuals, area of the worry steroid was cortisol; in rats it is corticosterone. HPA axis activity is regulated because of the several most other limbic system structures, such as the amygdala, which improves HPA axis craft, while the hippocampus, and therefore prevents HPA axis activation ( Fig. step three ).
This new HPA axis. Black colored range- Suppression union; dotted line- Facilitory partnership; dots and you can dashes range- Inhibition connection indirect path (via BNST or any other limbic regions); and you can dashed contours- Facilitory union indirect pathway (thru BNST or other limbic regions).
Standardized endocrine challenge tests to assess HPA axis activity include the dexamethasone suppression test and the CRF stimulation test. In the dexamethasone suppression test, systemic administration of dexamethasone, a synthetic glucocorticoid, decreases (ie, suppresses) plasma ACTH and cortisol concentrations via negative feedback at the level of the pituitary gland. In the CRF stimulation test, intravenously administered CRF (which does not enter the central nervous system) elevates plasma ACTH and cortisol concentrations by stimulating CRF1 receptors in the anterior pituitary. (Pokračování textu…)
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